Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other (...) diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors. (shrink)

Major depressive disorder (MDD) is a severe mental illness that affects 5 to 20% of the general population. Current antidepressant drugs exerts only a partial clinical efficacy because approximately 30% of depressed patients failed to respond to these drugs and antidepressants produce remission only in 30% of patients. This can be explained by the fact that the complex pathophysiology of depression has not been completely elucidated, and treatments have been mainly developed following the “monoaminergic hypothesis” of depression without considering the (...) key role of other factors involved in the pathogenesis of MDD, such as the role of chronic stress and neuroinflammation. Chronic stress acts as a risk factor for the development of MDD through the impairment of neurotrophins signaling such as brain-derived neurotrophic factor (BDNF) and transforming-growth-factor-β1 (TGF-β1). Stress-induced depressive pathology contributes to altered BDNF level and function in MDD patients and, thereby, an impairment of neuroplasticity at the regional and circuit level. Recent studies demonstrate that aerobic exercise strongly increases BDNF production and it may contribute as a non-pharmacological strategy to improve the treatment of cognitive and affective symptoms in MDD. Here we will provide a general overview on the possible synergism between physical activity and antidepressants in MDD. Physical activity can synergize with antidepressant treatment by rescuing neurotrophin signaling in MDD patients, promoting neuronal health and recovery of function in MDD-related circuits, finally enhancing pharmacotherapeutic response. This synergism might be particularly relevant in elderly patients with late-life depression, a clinical subgroup with an increased risk to develop dementia. (shrink)

We provide an alternative proof of the sequentialisation theorem for proof nets of multiplicative linear logic. Namely, we show how a proof net can be transformed into a sequent calculus proof simply by properly adding to it some special edges, called sequential edges, which express the sequentiality constraints given by sequent calculus.

Este artigo é parte de uma pesquisa mais ampla que analisa os processos sociais e culturais envolvidos na condição da monoparentalidade feminina, enfatizando jornadas exaustivas e responsabilização pela economia dos cuidados e reprodução social da vida. Objetiva-se analisar como as estruturas opressoras patriarcais afetam e refletem nas vivências de mulheres que exercem a maternidade solo. A investigação se deu a partir da seguinte questão: Como a sobrecarga e os estereótipos promovidos pelo patriarcado colonialista, por meio da divisão sexual do trabalho, (...) atingem as mães solo? Ancora-se na abordagem da história oral e autoetnográfica, na pesquisa social-qualitativa bibliográfica e no estudo de campo, sob a perspectiva espistemológica feminista interseccional e decolonial. Constata-se que os empecilhos promovidos por tais estruturas opressoras impedem ou adiam processos emancipatórios e alocam famílias monoparentais femininas em lugares de vulnerabilidade financeira, afetiva e social. Entretanto, apesar destes obstáculos, as mães solo do recorte pesquisado, resistem e lutam pela emancipação financeira, social e emocional. (shrink)

Communicating an unfavourable prognosis while maintaining patient hope represents a critical challenge for healthcare professionals. Duty requires respect for the right to patient autonomy while at the same time not doing harm by causing hopelessness and demoralisation. In some cases, the need for therapeutic privilege is discussed. The primary objectives of this study were to explore HPs’ perceptions of hope in the prognosis communication and investigate how they interpret and operationalise key ethical principles. Sixteen qualitative semistructured interviews with HPs from (...) different positions and experience, including doctors and nurses in four different departments, were conducted in the Ticino Cantonal Hospital, Switzerland. The interviews were recorded, transcribed verbatim and analysed using thematic analysis. HPs defined prognosis and patient hope as interdependent concepts related to future perspectives for subjective quality of life. Two main factors allow HPs to maximise the benefits and minimise the harm of their communication: respecting the patient’s timing and sharing the patient’s wishes. Time is required to reframe needs and expectations. Furthermore, communication needs to be shared by HPs, patients and their relatives to build common awareness and promote a person-centred approach to prognosis. In this process, interprofessional collaboration is key: doctors and nurses are complementary and can together guarantee that patients and relatives receive information in the most appropriate form when they need it. Organisational aspects and the HPs’ emotional difficulties, particularly in coping with their own despair, are barriers to effective communication that need further investigation. (shrink)

The new book of Francesca Pentassuglio on Aeschines has come to fill an essential vacuum. The studies on Socratic philosophies have an interesting history that combines moments of great recognition with others of almost total disrepair. They were prominent in Antiquity and constituted a space where many lines were connected and enhanced the quantity and quality of the philosophical dialogue. Nothing at that time could make us suspect their subsequent fate and the development of an enormous di...

The Treatise On Numbers develops a typical Plotinian inquiry about oneness and intelligible plurality, in which the analysis is based on the problem of the infinite inside the intelligible realm, as it seems to be presented in the socalled generation of numbers in Plato's Parmenides, where numbers are linked to Being, identified by Plotinus with the hypostasis of Intellect, and produce a process of unlimited division. In order to avoid this interpretation, Plotinus finds in other Plato's dialogues the proof that (...) number is an eidetic nature, encompassing all the intelligible entities, so that the infinite has to be interpreted as what is produced by calculus. Other arguments are rather depending on the model of the Old Academy, concerning the relationship between forms and numbers: Plotinus wonders if numbers come ontologically before forms and indeed he states right this position. Other aspects of Plotinus' investigation, which can be traced back to the Old Academy, are the distinction between two kinds of numbers and the doctrine of the unified number. This model of number, quite ambiguous, may be identified with the indefinite dyad, even though the former has to be conceived, differently from that of Old Academy, within a mono-polar framework, according to which the sole principle is the One. (shrink)

Introduction: Novel coronavirus is having a devastating psychological impact on patients, especially patients with cancer. This work aims to evaluate mood disorders of cancer patients undergoing radiation therapy during COVID-19 in comparison with cancer patients who underwent radiation therapy in 2019.Materials and Methods: We included all the patients undergoing radiation therapy at our department in two-time points and during the COVID-19 outbreak. All the patients were asked to fulfill a validated questionnaire, the Symptom Distress thermometer, and the Beck Depression Inventory (...) v.2. We took into account the COVID-19 outbreak and also sex, age, week of radiation treatment, and disease.Results: We included 458 patients, with a median age of 64 years. STAI-Y1 median score was 40, whereas the median score of SDT was five and BDI-2 median score was 11. STAI-Y1, SDT, and BDI-2 were significantly correlated with the COVID-19 outbreak, sex, week of treatment, and disease.Conclusions: The prevalence of mood disorders in patients undergoing radiation therapy is higher than expected and even higher during the COVID-19 outbreak. These measurements could be useful as a baseline to start medical humanities programs to decrease these scores. (shrink)

Il presente contributo indaga la questione del fondamento della legge morale ebraica sulla scorta dell’insegnamento di Samuel David Luzzatto (1800-1865). Egli afferma che le norme etiche sono insite nell’essere umano, ma questo non basta perché vengano rispettate: la rivelazione divina sostiene quindi la morale naturale, senza insegnare nulla di diverso da quest’ultima, ma fornendo un’adeguata propedeutica e prevedendo sanzioni e premi chiari. Soltanto il monoteismo, con il suo necessario corollario cultuale, può dunque fondare una morale efficace, che si manifesta essenzialmente (...) nel praticare umanità e giustizia verso tutti gli esseri umani. This paper investigates the Jewish moral law’s foundation according with teaching of Samuel David Luzzatto (1800-1865). He affirms that ethical norms come from human being, but this is not enough for them to be respected: therefore divine revelation supports natural morality, teaching the same, but providing adequate preparation and providing penalties and rewards. Only monotheism, with its necessary worships, can therefore found an effective morality. It appears essentially in humanity and justice towards all human beings. (shrink)